Bisphosphonate-related osteonecrosis of the jaw in randomized clinical trials
نویسندگان
چکیده
منابع مشابه
Bisphosphonate-related osteonecrosis of the jaw
Bisphosphonates (BPs) have been used for the management of bone metabolic diseases. Currently their therapeutic use has increased, as also have their adverse effects, one of the most important being the bisphosphonate-related osteonecrosis of the jaw (BRONJ), a complication of diffi cult treatment and solution. Until now, the physiopathology of BRONJ remains unclear, and its treatment is uncert...
متن کاملBisphosphonate-Related Osteonecrosis of the Jaw: Specificities
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe complication that has recently emerged in patients treated with intravenous bisphosphonates for malignant diseases. This complication usually presents after a minor local trauma during a dental treatment. Several etiopathogenic mechanisms of this pathological condition have been proposed, but no model can explain all morpholog...
متن کاملBisphosphonate-Related Osteonecrosis of the Jaw.
Bisphosphonates are agents commonly used in the treatment of osteoporosis, and in the management of metastatic bone disease, and of hypercalcaemia of malignancy. Any oral surgical procedure or traumatic event exposing bone to bacterial infection may precipitate osteonecrosis of the jaw in subjects who have been treated with bisphosphonates which suppress bone turnover and inhibit the angiogenes...
متن کاملBisphosphonate-related osteonecrosis of the jaw: the role of actinomyces.
The etiology of bisphosphonate-related osteonecrosis of the jaw is unknown but was initially postulated to be mediated by bisphosphonate accumulation within the jaws, resulting in avascular necrosis. Bisphosphonates may not be the primary cause. Actinomyces are an underrecognized agent in pathogenesis, and timely actinomycosis-specific treatment may improve outcome.
متن کاملMicrocirculatory aspects of bisphosphonate-related osteonecrosis of the jaw
RELATED TO THE SUBJECTS OF THE THESIS IV. A Janovszky, R Varga, A Szabó, D Garab, M Boros, J Piffkó. Microcirculatory consequences of chronic bisphosphonate treatment after tooth extraction in a rat model. Int J Oral Maxillo Surg. 2013;42:(11)1187.
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ژورنال
عنوان ژورنال: Breast Cancer Research and Treatment
سال: 2009
ISSN: 0167-6806,1573-7217
DOI: 10.1007/s10549-009-0466-2